Children with confirmed or suspect peanut allergy in whom an oral food challenge with peanut is performed
Conditions
Interventions
none
Sponsors
OLVG
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for dietary analysis and quality of life scores • All children eligible for an open or double-blind peanut challenge. • Presence of IgE to peanut ≥0.35 kU/l. Inclusion criteria for microbial characterization • Children with a positive open or double-bind, placebo-controlled challenge with peanut • Presence of IgE to peanut ≥ 0.35 kU/l.
Exclusion criteria
Exclusion criteria: Exclusion criteria • Children not eligible for peanut challenge, according to protocol • Absence of IgE to peanut • A negative peanut challenge • Antibiotic use shorter than 3 months prior to the oral food challenge
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relationship between composition of the diet, composition of the microbiome and the reactive dose (threshold levels) in positive Open peanut challenge or DBPCFC with peanut. | — |
Secondary
| Measure | Time frame |
|---|---|
| In children, while on a peanut free diet, with a negative or positive peanut challenge: 1. Intake of foods, food groups, macro- and micronutrients while on peanut free diet 2. Quality of life scores 3. Amount of food-derived microbes in diet In children, while on a peanut free diet, with a positive peanut challenge 4. Microbiome characterization of oral cavity 5. Microbiome characterization of the gut. | — |
Contacts
Public ContactB.J. Vlieg-Boerstra
PO Box 95500, Department of Paediatrics
Outcome results
None listed