Self-Management of Altered environmental Reactivity Training SCANning.

Novel Self-management Techniques for Early Expression of Psychopathology: An Experimental Study Linking Neural and Mental State reactivity Phenotypes.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON24727

Enrollment

198

Registered

2013-01-22

Start date

2013-03-01

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Young people in the earliest phase of expression of psychopathology

Interventions

1. Psychosis & Depression Trial: The verum condition consists of a 4 session ACT-training, during 6 weeks of ESM assessments with signals at random time-points to fill out questionnaires, followed by

2. Anxiety Trial: Exposure therapy in the clinical condition of phobia. The control condition consists of relaxation training.

Eligibility

Inclusion criteria

Inclusion criteria: Two samples of adolescents / young adults aged 16-25 years with sub-diagnostic, subclinical stage 1b levels of depression and or psychosis (MADRS≥10 and/or CAPE≥12, and GAF<70, following the guidelines of McGorry et al [1] corresponding with approximately 15% of the general population) (n=132), fear (n=66), as well as a comparison group with no/low level of psychopathology (n=50) based on the rating-scores of psychopathology using questionnaires will be studied.

Exclusion criteria

Exclusion criteria: Exclusion criterion is receiving a current psychological or psychiatric treatment or significant need for care. Contra-indications for (f)MRI are use of pacemaker, metal implants, pregnancy or a history of claustrophobia. Past recovery from depression, psychosis or anxiety disorder is not an exclusion criterion as this would not impact the outcome measures.

Design outcomes

Primary

Measure	Time frame
Neuroimaging effects: The primary outcome measure in the intervention study is the pre/post intervention change of fMRI BOLD signal in the regions of interest involved in aversive learning, in reward learning and in anticipation of reward. The primary outcome measure in the observational study is the pre/post follow-up period change of fMRI BOLD signal in the regions of interest involved in aversive learning, in reward learning and in anticipation of reward.	—

Measure

Time frame

Neuroimaging effects: The primary outcome measure in the intervention study is the pre/post intervention change of fMRI BOLD signal in the regions of interest involved in aversive learning, in reward learning and in anticipation of reward. The primary outcome measure in the observational study is the pre/post follow-up period change of fMRI BOLD signal in the regions of interest involved in aversive learning, in reward learning and in anticipation of reward.

—

Secondary

Measure	Time frame
Secondary outcomes: 1. Reward experience; 2. Stress reactivity and salience reactivity as measured with ESM; 3. Cross-sectional associations between fMRI and ESM and psychopathology. Ancillary outcomes: Changes in depression, psychosis and fear psychopathology scores.	—

Contacts

Public ContactJ. Os, van

P. Debyelaan 25 Postbus 5800

j.vanos@maastrichtuniversity.nl+31 (0)43 3875443

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)