Exercise induced bronchoconstriction after hospitalisation for lower respiratory tract infection in infancy.

EIB after VLRTI.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON24718

Enrollment

120

Registered

2011-11-08

Start date

2011-12-01

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma, exercise induced asthma, exercise induced bronchoconstriction, bronchiolitis, lower respiratory tract infection

Interventions

No intervention, other than an exercise provocation challenge, will be investigated. An exercise provocation challenge is part of the routine clinical evaluation of patients with exercise induced symp

Eligibility

Inclusion criteria

Inclusion criteria: 1. History of hospitalisation for viral lower respiratory tract infection (VLRTI) <2 years of age (children will be recruited from the VLRTI-cohort); 2. Age 5 through 7 years; 3. Ability to perform reproducible lung function tests, i.e. coefficient of the predicted value variation in 3 of 5 consecutive measurements < 5%; 4. Clinically stable period at least 4 weeks before the study period (no hospital admission or use of systemic corticosteroids).

Exclusion criteria

Exclusion criteria: 1. Use of systemic corticosteroids in the last 4 weeks prior to the study; 2. Use of long acting bronchodilators 24 hours before testing; 3. Use of short acting bronchodilators 8 hours before testing; 4. Use of leukotriene antagonists 24 hours before testing; 5. Comorbidity (other pulmonary or cardiac disorder, mental retardation/motor dysfunction).

Design outcomes

Primary

Measure	Time frame
Primary outcome of this study is to investigate the prevalence of EIB in young children with a history of hospitalisation for VLRTI. Primary parameter is the percent change in pulmonary function (FEV1, FEV0.5 and FEF50) during and post-exercise in young children, hospitalised in infancy with VLRTI.	—

Secondary

Measure	Time frame
1. Prevalence of EIB in young children with a history of hospitalisation for VLRTI with regard to different pathogens (especially RSV versus RV); 2. Analysis of anthropometric measures, clinical features, medication use and history of young children with a history of hospitalisation for VLRTI; 3. Investigate whether the prevalence of asthma in young children with a history of hospitalisation for VLRTI significantly differs from the prevalence of asthma in the general population (based on literature data).	—

Measure

Time frame

1. Prevalence of EIB in young children with a history of hospitalisation for VLRTI with regard to different pathogens (especially RSV versus RV); 2. Analysis of anthropometric measures, clinical features, medication use and history of young children with a history of hospitalisation for VLRTI; 3. Investigate whether the prevalence of asthma in young children with a history of hospitalisation for VLRTI significantly differs from the prevalence of asthma in the general population (based on literature data).

—

Contacts

Public ContactJ.C. Leeuwen, van

Department of pediatrics, VKC poli 17 Haaksbergerstraat 55

vanleeuwen.janneke@gmail.com+31 (0)53 4872310

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)