20 healthy volunteers will be exposed to either provocation with xylometazoline nasal spray or placebo.
Conditions
Interventions
The microcirculation of the nasal mucosa of healthy controls will assessed using a non invasive probe, diameter 0.5 cm, which will be placed in the nasal cavity, twice for a period of approximately 10
Sponsors
Academic Medical Center, Amsterdam.
Department of Otolaryngology and Clinical Physiology
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with active allergic rhinitis, idiopathic rhinitis, chronic rhinosinusitis or nasal polyps; 2. Males or females aged over 18 years with no maximum age; 3. Approval of the patient’s physician; 4. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Smoking; 2. Severe cardiac or pulmonary disorder; 3. Peripheral vascular disease; 4. Medication: systemic: â blockers, corticosteroids (local and systemic); any local nasal treatment; bronchodilatory inhalation medication for pulmonary diseases > 1000 ìg/day; 5. Cystic fibrosis, Immotile cilia syndrome, Rendu-Osler-Weber disease, vasculitis; 6. Cocaine and/or alcohol abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The following parameters will be used to asses the microcirculatory reaction after provocation: Flow in the capillary, venules and arterioles can be scored semi quantitatively or quantitatively: 1. Semi quantitative scoring: (0 = no flow, 1 = intermittent flow, 2 = sluggish flow and 3 = continuous flow); 2. Quantitative scoring: (velocity, flow, diameter, length, density). | — |
Contacts
Public ContactW.J. Fokkens
Academic Medical Center (AMC), Department of Otorhinolaryngology, Room A2-234, P.O. Box 22660
Outcome results
None listed