Oral vitamin B12 supplementation and cognitive performance in elderly people.

The effect of oral vitamin B12 supplementation on cognitive performance in elderly people.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON24656

Enrollment

195

Registered

2005-09-09

Start date

2003-05-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild vitamin B12 deficiency.

Interventions

1. 1,000 microgram vitamin B12/day

2. 1,000 microgram vitamin B12 + 400 microgram folic acid/ day

3. Placebo.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Men and women aged 70 years or older; 2. Mild vitamin B12 deficiency defined as vitamin B12 concentration between 100 and 300 picomol/L and MMA concentration > 0.32 micromol/L and creatinine concentration < 120 micromol/L.

Exclusion criteria

Exclusion criteria: 1. Severe cognitive impairment; 2. Anemia; 3. Gastrointestinal surgery; 4. Use of vitamin B12 injections or supplements containing > 50 micrograms vitamin B12 and/or 25 micrograms folic acid; 5. < 90% compliance during a 2 week placebo run in perfiod; 6. No written informed consent; 7. Participation in other studies.

Design outcomes

Primary

Measure	Time frame
Cognitive performance.	—

Secondary

Measure	Time frame
Blood biochemistry.	—

Contacts

Public ContactSimone Eussen

Wageningen University, Division of Human Nutrition, P.O. Box 8129

simone.eussen@wur.nl+31 (0)317 485395

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)