SARS-CoV-2
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC, location AMC
Eligibility
Inclusion criteria
Inclusion criteria: - Adult (age = 18 years) - Screened for COVID-19 according to the national guidelines because of a planned surgical or interventional procedure under general anesthesia. - Tested positive for SARS-CoV-2 with RT-PCR. - Asymptomatic at the moment of screening: no suspicion for COVID-19 for at least 48 hours prior to screening, based on a standardized questionnaire containing the following complaints: cough, dyspnoea, fever, general malaise, myalgia, headache, extreme fatigue (new onset), throat ache, obstructed/runny nose, loss of smell, loss of taste, abdominal pain, diarrhoea and vomiting.
Exclusion criteria
Exclusion criteria: - Not able or willing to give informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective is to determine the quantity and quality of antibody and T-cell responses to SARS-CoV-2 in asymptomatic patients who tested positive for SARS-CoV-2 with RT-PCR prior to interventions. | — |
Secondary
| Measure | Time frame |
|---|---|
| - To determine the level of serum antibody response to other (seasonal) coronaviruses. - To evaluate the effect of age, comorbidity and RT-PCR cycling threshold values as predictors for immune responses to SARS-CoV-2. - To evaluate the development of antibody and T-cell responses over time (up to one year after positive testing). - To compare levels of antibody and T-cell responses to SARS-CoV-2 of asymptomatic patients with those of mild and severe symptomatic patients with laboratory-confirmed COVID-19 | — |
Contacts
Public ContactAnnemieke van den Broek
Amsterdam UMC, location AMC
Outcome results
None listed