accumulation of Nadroparine during hemodialysis
Conditions
Interventions
The use of 4 bloodsamples taken from the dialysisline to determine anti-Xa activity (IU/ml)
Sponsors
Stichting wetenschap Internegeneeskunde & MDL, Medisch Centrum Leeuwarden.
Eligibility
Inclusion criteria
Inclusion criteria: Patients (18<years of age) ondergoing nocturnal hemodialysis
Exclusion criteria
Exclusion criteria: - The use of other drugs wich block factor-Xa other than nadroparine. This includes dabigatran, apixaban, rivaroxaban, LMWH’s, heparine and fondaparinux. - The use of Cofact or Beriplex during measurements - Alteration in the dosage regime of anticoagulantia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anti-Xa activity (IU/ml) before and after the first and last dialysis of the week to determine if accumulation occurs. | — |
Secondary
| Measure | Time frame |
|---|---|
| -Bloodflow during dialysis -Flow of dialysis fluids -Renal function -Kt-V -Bleeding events -Clotting in the dialysis filter | — |
Contacts
Public ContactM.H. Hemmelder
H. Dunantweg 2
Outcome results
None listed