candidates for brain surgery with epilepsy and/or brain tumours.
Conditions
Interventions
Language and memory areas will be localised using Magnetoencephalography (MEG). The effectiveness of the protocol will be evaluated by comparison with Wada (intracarotid sodium amobarbital procedure)
Sponsors
VUmc
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 85; 2. Has had, or will undergo, a Wada test; 3. Will undergo a MEG and MRI scan as part of a pre-surgical evaluation; 4. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Unable to undergo an MRI scan; 2. Insufficient mastery of the Dutch language; 3. Inability to communicate adequately.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The raw recorded MEG signals will be post-processed according to standard procedures, and artefact-free epochs will be selected by an experienced investigator. These epochs are then used to localise underlying neuronal activity using an MEG beamformer, in combination with the patient’s anatomical MRI. A lateralisation index will be computed on the basis of the reconstructed task-related neuronal power changes. In addition, a lateralisation index will be obtained from the Wada procedure by experienced neuropsychologists who are blinded to the MEG results. | — |
Secondary
| Measure | Time frame |
|---|---|
| The lateralisation index computed on the basis of MEG and Wada, respectively, will be compared. | — |
Contacts
Public ContactAlexandra M.E. Linger
Klinische Neurofysiologie/Magneto-encefalografie VU medisch centrum Receptie C PK -1 Z kamer 150 de Boelelaan 1118
Outcome results
None listed