Allergy
Conditions
Interventions
None
Sponsors
Investigator initiated- Amsterdam university medical centers
Eligibility
Inclusion criteria
Inclusion criteria: There are three categories of subjects for blood donation: ? Subjects with doctor-diagnosed allergic rhinitis ? Subjects with doctor-diagnosed non-allergic rhinitis ? Healthy subjects, defined as not having allergic or non-allergic rhinitis or other inflammatory non-communicable diseases such as rheumatoid arthritis, type 2 diabetes, celiac disease, colitis ulcerosa, Chrohn’s disease, and multiple sclerosis. All three categories should meet the following additional criteria: • Age between 18 and 65. • Signed informed consent.
Exclusion criteria
Exclusion criteria: • History of AIT (SCIT or SLIT) with any allergen within the past year at the time of blood donation. • Ongoing AIT (SCIT or SLIT) with any allergen at the time of blood donation. • Vaccination within one week before blood donation. • Immunosuppressive or biological medication (e.g. IL-5, anti-IgE therapy) within the last six months prior to blood donation. • Severe immune disorders (including auto-immune diseases) and/or diseases requiring immunosuppressive drugs. • Active malignancies or any malignant disease during the previous 5 years. • Active inflammation or infection at the time of blood donation. • Use of systemic steroids within 4 weeks before the blood donation. • Treatment with systemic and local ß-blockers. • Subjects who are students or employees of the institution or 1st grade relatives or partners of the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of the study is to obtain a blood sample for isolation of monocytes. These monocytes will be used to generate monocyte-derived dendritic cells (moDC). | — |
Contacts
Public ContactLaurian Jongejan
Amsterdam university Medical centers
Outcome results
None listed