TMJ osteoarthritis
Conditions
Interventions
Arthrocentesis of the temporomandibular joint and subsequent injection of adipose-derived stromal vascular fraction
Sponsors
UMCG
Eligibility
Inclusion criteria
Inclusion criteria: • Age between 18-70 years • Chronic nociceptive pain in the TMJ region, aggravated by protrusion, maximal mouth opening, lateral excursions and/or chewing of at least 2 months • Wilkes stages III or IV (internal derangement) • Limited maximal interincisal opening ( 15 mm) • Pain still present after two weeks of a NSAID (i.e. ibuprofen 600 mg three times daily, or diclophenac 50 mg 3td, or napoxen 500 mg 2 td) • Pain disappears after diagnostic intra-articular injection
Exclusion criteria
Exclusion criteria: • Edentulous (no dentition) • Previous treatments acting on cartilage or bone metabolism (eg, oral or intravenous bisphosphonates <1 year previously, strontium ranelate or teriparatide or raloxifene <7 days prior to selection, and oral glucosamine =1500 mg/day and chondroitin sulphate <3 months previously) • Concurrent use of anti-inflammatory medication, steroids, muscle relaxants or antidepressants • Previous TMJ traumas and fractures • Previous TMJ surgeries, previous intra-articular injections < 1 year before • Bilateral severe TMJ derangements • Bony or fibrotic ankylosis of the TMJ • Known history of diabetes mellitus type 1 or 2 • Known history of HIV • Serious systemic diseases, rheumatic disease or infectious/inflammatory diseases affecting the skin of the area of the TMJ • Pregnancy • Coagulation disorders • BMI <15
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain and maximal interincisal mouth opening | — |
Secondary
| Measure | Time frame |
|---|---|
| Influence on oral health and mandibular function | — |
Contacts
Public ContactJan Aart Schipper
University Medical Centre Groningen (UMCG)
Outcome results
None listed