neonatal seizures in fullterm infants following perinatal asphyxia
Conditions
Interventions
Following initiation of aEEG registration and the occurrence of the first subclinical seizure, and following parental consent, the infant will be randomised to group A (treatment of clinical as well s
Intermittent standard EEG can be performed and in case the EEG shows a status epilepticus this can be treated, but in case a subclinical seizure is seen on the standard EEG, this will not be treated w
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: Fullterm infants admitted to the neonatal intensive care unit, within the first 24 hours after birth with subclinical seizures on the aEEG, in 8 Dutch and 3 Belgium centres.
Exclusion criteria
Exclusion criteria: Preterm infants (<37 wks GA) and fullterm infants with neonatal seizures admitted after the first 24 hours after birth. Infants with chromosomal disorders, congenital anomalies and meningitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. What is the number of electrographic seizure discharges missed if you do not monitor continuously; 2. Does instantaneous treatment of electrographical seizures lead to: a. A reduction of seizure discharges; b. Less damage on the neonatal MRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Does treatment of neonatal seizures lead to a reduced risk of postneonatal epilepsy (PNE) and d) an improved neurodevelopmental outcome at 24 months. | — |
Contacts
Public ContactL.S. Vries, de
University Medical Center Utrecht (UMCU), P.O. Box 85090
Outcome results
None listed