Glucose metabolism in Familial Hypobetalipoproteinemia.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON24590

Enrollment

Registered

2006-04-18

Start date

2006-05-11

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

A hyperinsulinaemic clamp will be performed for 4½ hours using stabile isotopes (d2-glucose and D5-glycerol). Additionally, muscle biopsies will be taken and fat distribution will be studied by a DEXA

Eligibility

Inclusion criteria

Inclusion criteria: 1. Male; 2. Age > 18 y; 3. BMI 20-35 kg/m2.

Exclusion criteria

Exclusion criteria: 1. Known somatic illness; 2. Use of medication influencing metabolism/ blood clotting; 3. Seropositive for HbsAg, HbcAg, HCV, HAV or HIV; 4. Having metal device in the body.

Design outcomes

Primary

Measure	Time frame
1. Insulin sensitivity at the level of glucose production by liver, glucose uptake by muscle+fat and lipolysis; 2. Fat distribution by a DEXA-, a CT-scan and MRS-spectroscopy.	—

Secondary

Measure	Time frame
1. Lipid levels; 2. Glucoregulatory levels; 3. (Adipo)cytokines.	—

Contacts

Public ContactR. Blumer

Academic medical Center (AMC), Department of Endocrinology and Metabolism, F5-162, P.O. Box 22660

r.blumer@amc.uva.nl+31 (0)20 5669111

Outcome results