Fatty Acid Induced Oxidative Stress: it's role in preventing hypoglycemia.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON24578

Enrollment

Registered

2005-11-03

Start date

2006-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

1. Insulin resistance in non-obese fasting

Interventions

Subjects will undergo a period of fasting and are assigned to receive either acipimox (inhibitor lipilysis) 250mg 4dd or placebo. Hereafter insulin sensitivity will be measured using stable isotope te

Eligibility

Inclusion criteria

Inclusion criteria: 1. 6 healthy men; 2. 18-38 years; 3. BMI 20-25; 4. stable weight during the last 3 months.

Exclusion criteria

Exclusion criteria: 1. Diabetes; 2. diabetes first degree relatives; 3. hypercholesterolemia; 4. high intensity sport activities; 5. positive oral glucose tolerance testing.

Design outcomes

Primary

Measure	Time frame
Insulin resistance, Free fatty acids and oxidative stress with and without acipimox.	—

Secondary

Measure	Time frame
Other measures of glucosehomeostasis: glucoregulatory hormones, (adipo)cytokines.	—

Contacts

Public ContactM.R. Soeters

Academic Medical Center (AMC) Department of Endocrinology & Metabolism, F5-162 P.O. Box 22660

m.r.soeters@amc.uva.nl+31 (0)20 5669111

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)