Primary and revision total knee (TKR)-and hip replacement (THR) surgery patients.
Conditions
Interventions
Stratification depending on the pre-operative Hemoglobin (Hb) level:
Stratum I: 6,1 mmol/L 8,1 mmol/L (not eligible for Epo).
Patients in both strata will be sequentially randomised for:
a. no use of
Sponsors
LUMC, department of Orthopaedics
Eligibility
Inclusion criteria
Inclusion criteria: All orthopedic patients of 18 years and older being considered for a primary or revision total knee replacement (TKR) or total hip replacement (THR).
Exclusion criteria
Exclusion criteria: Refusal of allogeneic blood, pregnancy, patients with uncontrolled hypertension, cardiac instability, recent CVA, symptomatic atherosclerosis, sickle cell anaemia, cancer in the wound area , unsuitability for peri-operative anticoagulation prophylaxis, known allergy to erythropoietin and patients with an infected prosthesis or wound.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of red blood cell (RBC) transfusions in the following blood management strategies: 1. Comparison of Epo versus no Epo; 2. Comparison of cell saver versus no cell saver; 3. Comparison of drain system versus no drain system, independent of cell saver. | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative complications, length of hospital stay (LOHS), postoperative Hb/haematocrit (Hct), rehabilitation time, mobility and functional abilities of knee-or hip, quality of life scores, costs analysis. | — |
Contacts
Public ContactCynthia So-Osman
Sanquin Bloodbank ZW, Plesmanlaan 1a
Outcome results
None listed