Pleural empyema, complicated parapneumonic effusion
Conditions
Interventions
None listed
Sponsors
Not applicable.
Eligibility
Inclusion criteria
Inclusion criteria: - Age = 18 years - Diagnosed with pleural empyema or complicated parapneumonic effusion, based on the criteria mentioned below, and in need of pleural fluid drainage. o presence of pus or positive Gram’s stain or culture from the pleural fluid. o pleural pH1000 IU/L - Receiving IV amoxicillin 1000mg 4 times daily or amoxicillin-clavulanic acid 1000/200mg 4 times daily; dosage if necessary adapted to renal function - Able and willing to give informed consent (or consent by family member or legal representative)
Exclusion criteria
Exclusion criteria: - Critically ill patients admitted to the ICU, or patients of the general ward who became critically ill and got transferred to the ICU during the duration of the study. - Pre-existing ipsilateral pleural effusion or other cause of pleural effusion (e.g. cancer) more likely.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The probability of target attainment in pleural fluid of intravenous amoxicillin(-clavulanic acid) | — |
Secondary
| Measure | Time frame |
|---|---|
| The penetration ratio of the antibiotics from blood plasma to pleural fluid, expressed as the fAUC0-6/8 of pleural fluid divided by the fAUC0-6/8 of plasma. | — |
Contacts
Public ContactAnnemieke van den Broek
Amsterdam UMC, location AMC
Outcome results
None listed