Nontuberculous mycobacterial cervicofacial lymphadenitis
Conditions
Interventions
Swabs of the tongue, tonsils and gingiva are taken from patients with suspected NTM cervicofacial lymphadenitis. Moreover, blood samples are taken. All procedures are performed during surgery.
Sponsors
Board of directors Academic Medical Center, Amsterdam. (This study is an investigator initiated study)
Eligibility
Inclusion criteria
Inclusion criteria: Age between 0-11 years High clinical suspicion of NTM cervicofacial lymphadenitis with indication for surgical treatment, as defined by the following factors; Cervicofacial lymphadenopathy for a period longer than 3 weeks Typical clinical presentation as defined by Penn et al., 2011. (6) Negative serologic tests for other kinds of (sub) chronical lymphadenopathy: Epstein-Barr virus, cytomegalovirus, Bartonella species, Adenovirus, and toxoplasmosis Ultrasonographically, hypoechoic lymph nodes, often with central necrosis, nodal matting and adjacent soft tissue oedema
Exclusion criteria
Exclusion criteria: Known immunodeficiencies Use of immunosuppressive drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity and specificity of the Capilia mac antibody Elisa test | — |
Secondary
| Measure | Time frame |
|---|---|
| The assessment of microbial composition and identification of NTM in the oral cavity, oropharynx and excised lymph node material. | — |
Contacts
Public ContactSam Willemse
Amsterdam UMC, locatie AMC
Outcome results
None listed