Hypertension Cerebral Small Vessel Disease (CSVD) Hypertensie Cerebrale wittestofschade
Conditions
Interventions
intensive control (SBP ≤
120 mmHg)
Sponsors
VU University Medical Centre
Eligibility
Inclusion criteria
Inclusion criteria: • ≥ 65 years of age • High systolic blood pressure of 150-200mmHg based on the average of a daytime 24-hour BP (with or without taking antihypertensive medication) • Cerebral small vessel disease (white matter lesions; Fazekas score ≥ 2) on MRI
Exclusion criteria
Exclusion criteria: • Medical history of diabetes mellitus • Experienced myocardial infarction within the past 12 months • Medical history of stroke in the past 6 months or large (sub) cortical cerebral infarction on MRI • Medical history of end stage heart failure (NYHA III-IV) • Stage 4-5 kidney failure • Diagnosed with dementia • Life expectancy less than 1 year • Unable to obtain an optimal window for TCD measurements during first visit at the outward patient clinic • Significant stenosis (>70%) of the left of right common carotid artery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cerebral blood flow velocity | — |
Secondary
| Measure | Time frame |
|---|---|
| cognitive functioning, white matter lesions, orthostatic hypotension, dynamic cerebral autoregulatory capacity, CO2 responsiveness, experienced side effects, disability to reach assigned BP target | — |
Contacts
Public ContactEmma Kleipool
Dept. Internal Medicine/Geriatrics, ZH 4A74
Outcome results
None listed