Non-invasive characterization of paediatric brain tumours using metabolic imaging at high magnetic field

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON24537

Enrollment

Registered

2020-01-10

Start date

2020-03-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ow grade glioma (LGG) and diffuse pontine glioma (DIPG)

Interventions

MRI at 7T

Eligibility

Inclusion criteria

Inclusion criteria: - Children, 5-18 years diagnosed with a possible low grade glioma (LGG) or diffuse pontine glioma (DIPG) - Children must be able to undergo MRI without anaesthesia; - Informed and having given informed consent (either by patient and / or parents / legal guardian).

Exclusion criteria

Exclusion criteria: - The presence of claustrophobia; - Patients from who it is known at the time of inclusion that they will undergo tumour resection within 1 month; - MRI-specific exclusion criteria, such as metal implants. Screening for MRI specific exclusion criteria will be done using the regular MRI (at 7 Tesla) safety screening. - Refusal or inability to provide informed consent by patient and / or parent / legal guardian.

Design outcomes

Primary

Measure	Time frame
To determine whether metabolic imaging at 7 Tesla is feasible and suitable to detect changes in phospholipids and APT levels in paediatric brain tumours	—

Secondary

Measure	Time frame
· To investigate the use of non-invasive metabolic imaging to evaluate treatment effects of paediatric brain tumours; · To investigate the use of non-invasive metabolic imaging to evaluate aggressiveness of paediatric brain tumours and if available compare it with histology and molecular biology	—

Contacts

Public ContactEvita Wiegers

UMC Utrecht

e.c.wiegers@umcutrecht.nl0031887553197

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)