Barrett's esophagus Buried Barrett's Barrett slokdarm
Conditions
Interventions
The study uses the VLE catheter to examine and scan the distal Barrett's esophagus. VLE is an advanced imaging technique that has the potential to visualize subsquamous structures in Barrett's esophag
Sponsors
AMC Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age > 18 – 80 years; 2. Patients post RFA treatment with 100% endoscopic regression of Barrett’s epithelium; 3. Minimum circumferential Barrett’s extent of 2 cm prior to ablation therapy; 4. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Presence of significant stenosis; 2. Presence of erosive esophagitis; 3. Inability to undergo ER and/or obtain biopsies (e.g. due to anticoagulation, coagulation disorders, varices); 4. Unable to provide signed informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Presence of structures suggesting BB on VLE; 2. VLE characteristics of buried glands (e.g. sparsely distributed hyposcattering structures underneath NSE with various sizes and shapes) ; - Number of glands; - Size of glands ; - Location of glands from GEJ; - Depth level of glands 3.Presence of structures suggesting of BB in ER specimens and, if present: - Number of glands - Size of glands - Location of glands from GEJ - Depth level of glands 4. Histology: Intestinal metaplasia, Dysplasia Correlation of OFDI images with corresponding histology of ER specimen | — |
Contacts
Public ContactJ.J.G.H.M. Bergman
Academic Medical Center Bldg. C2-210, Meibergdreef
Outcome results
None listed