Diabetes mellitus 2 (ouderdomssuikerziekte) Aortic elasticity (flexibiliteit van de aorta)
Conditions
Interventions
Subjects will arrive after an overnight fast. A cannula will be inserted for blood drawing during the MRI scan. MRI scan will be performed to measure baseline cardiac function, abdominal waist fat and
Sponsors
Leiden University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: 1. Impaired fasting glucose (fasting glucose 5.6-6.9 mmol/l); 2. Age 18-75 years; 3. Informed consent. Controls: 1. Subjects with normal fasting glucose matched for age (18-75), BMI, blood pressure and gender; 2. Informed consent.
Exclusion criteria
Exclusion criteria: 1. Fasting plasma glucose =/. 7 mmol/l or previously diagnosed T2DM; 2. Grade 2 or 3 hypertension at screening according to ESC guidelines 2007; 3. Use of medication; antihypertensives, glucose lowering medication, statins of fibrates; 4. Any significant chronic disease; 5. Renal, hepatic or other endocrine disease; 6. Smoking; 7. Pregnancy; 8. Contra-indications MRI; 9. Recent participation in other research projects in one year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Magnetic resonance imaging: Aortic pulse wave velocity; 2. Heart rate variability. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Heart dimensions: End-diastolic volume, end systolic volume, LV mass, LV mass index, LVMI/EDVI; 2. Heart function: Systolic function (stroke volume, ejection fraction, cardiac output, cardiac index, peak ejection rate), diastolic function (early peak filling rate E, early deceleration peak, atrial peak filling rate A, E/A ratio, peak mitral annulus longitudinal motion, MR estimate of LV filling pressure); 3. Body fat distribution; 4. Glucose and insulin levels. | — |
Contacts
Public ContactN. Tjeerdema
Department Internal Medicine / Endocrinology, C4 70
Outcome results
None listed