Pediatric brain tumors
Conditions
Interventions
None listed
Sponsors
Princess Máxima Center for Pediatric Oncology
Eligibility
Inclusion criteria
Inclusion criteria: - Age 0 – 18 years at inclusion - Newly diagnosed brain tumor or relapse of a brain tumor - MRI representing an image of a high grade brain tumor (high grade glioma, ependymoma, ATRT, medulloblastoma, or otherwise high grade) OR CNS tumor where based on MRI images the judgement of high grade versus low grade can’t be made. NB in case MRI imaging prior to biopsy and/or resection is not feasible, the patient can be included based on CT imaging and clinical assessment - Clinical indication for tumor biopsy/resection - Written (parental) informed consent
Exclusion criteria
Exclusion criteria: - Suspected germ cell tumor on radiology or based on tumor markers (aFP, ßHCG) - Suspected craniopharyngioma on radiology - Clear characteristics of low grade tumor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Descriptive characterisation of lymphoid and myeloid subsets and activation status in different compartment, e.g. tumor microenvironment, blood, bone marrow, and CSF at different timepoints | — |
Secondary
| Measure | Time frame |
|---|---|
| Descriptive characterisation of lymphoid and myeloid subsets and activation status in different compartment, e.g. tumor microenvironment, blood, bone marrow, and CSF before after and during treatment Multivariate regression analysis of lymphoid and myeloid subsets and activation status in the different compartments in relation to overall survival and event free survival (event = relapse or death of any cause) response to therapy | — |
Contacts
Public ContactRaoull Hoogendijk
Princess Máxima Center for Pediatric Oncology
Outcome results
None listed