Study on the effect of prednisolone on muscle strength and mobility

Prospective observational study of toxicity from high-dose glucocorticoids used in induction treatment for ANCA associated vasculitis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON24482

Enrollment

Registered

2015-06-18

Start date

2015-09-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ANCA associated vasculitis, Steroid myopathy, Glucocorticoid toxicity

Interventions

No interventions. Only additionional non-invasive measurements will be performed

Eligibility

Inclusion criteria

Inclusion criteria: Patients with new onset or relapse of Granulomatosis with Polyangiitis or Microscopic Polyangiitis, who have an indication of induction treatment with cyclophosphamide (or other immunosuppressive) and prednisolone (1mg/kg/day, dosage according to treatment protocol)

Exclusion criteria

Exclusion criteria: Patients <18 years

Design outcomes

Primary

Measure	Time frame
-Strength of knee extension and hip flexion (N), measured by handheld dynamometer -Mobility (average kcounts/day), measured by accelerometer -Physical summary score of RAND-36	—

Secondary

Measure	Time frame
These include anthropometric measures, strenght of elbow flexors, bioelectric impedance analysis, five-times sit-to-stand transfer and mobility questionnaires	—

Contacts

Public ContactArno Hessels

University Medical Center Groningen, Triade gebouw C1.06

a.c.hessels@umcg.nl+31503615838

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)