Early detection of bacteria in bloodstream infections: implications for patient care.

Early detection of bacteria in bloodstream infections using molecular diagnostics: implications for patient care.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON24453

Enrollment

340

Registered

2009-10-06

Start date

2009-10-12

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bloodstream infection, sepsis, rapid antibiotic susceptibility testing

Interventions

In patients randomised for the intervention group, a new, rapid method for antibiotic susceptibility testing directly on positive blood cultures will be used. This method combines culture and PCR. The

Eligibility

Inclusion criteria

Inclusion criteria: All patients in the Maastricht University Medical Center with a positive blood culture are eligible for inclusion.

Exclusion criteria

Exclusion criteria: 1. Age under 18; 2. A blood culture containing streptococci, coagulase-negative staphylococci, anaerobes or multiple species; 3. A positive blood culture in the previous 3 days.

Design outcomes

Primary

Measure	Time frame
Primary endpoint is reduction in time that a broad-spectrum or inappropriate antibiotic therapy is used.	—

Secondary

Measure	Time frame
Secondary outcomes: 1. Length of hospital stay; 2. Implementation of the advise of the medical microbiologist regarding antibiotic therapy by the patients’ physician; 3. Adverse effects of antibiotic use; 4. Mortality; 5. Economic evaluation.	—

Contacts

Public ContactP.F.G. Wolffs

Department of Medical Microbiology Maastricht University Medical Center P.Debeyelaan 25

p.wolffs@mumc.nl+31 (0)43-3876644

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)