total hip arthroplasty, knee arthroscopy, immune response, monocyte populations
Conditions
Interventions
5mL of peripheral blood will be drawn preoperatively and postoperatively, with a small margin, at 2 hr, 6 hr, 24 hr, 36 hr, 48 hr and 1 week. After blood samples have been obtained from the patients,
C to the LUMC laboratory site for analysis.
Sponsors
Martini Hospital Groningen
Eligibility
Inclusion criteria
Inclusion criteria: - elective knee arthroscopy or an elective total hip arthroplasty (posterolateral approach) for primary osteoarthritis - between 18 and 70 years of age - signed informed consent
Exclusion criteria
Exclusion criteria: - pre-existing immune deficiency - use of immunosuppressant drugs - orthopaedic surgery in the last two years - cognitive impairments - Evident infectious complications such as pneumonia, surgical site infection (SSI) and/or urinary tract infection (UTI), during postoperative course
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression of early and late markers that identify the maturation stage of monocyte subpopulations. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Absolute numbers of monocyte subpopulations and lymphocyte populations. - Serum interleukines and classical tissue damage marker (CRP and CK) levels. | — |
Contacts
Public ContactA.J. Vries, de
University Medical Center Groningen (UMCG), Department of Anesthesiology, P.O. Box 30001
Outcome results
None listed