Obesity and COVID-19: AdipoSe TissuE Responses to SARS-CoV-2 infection

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON24411

Enrollment

Registered

2020-12-23

Start date

2020-12-23

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19

Interventions

We will collect human visceral and subcutaneous adipose tissue samples in order to investigate the adipose tissue responses to ex vivo SARS-CoV-2 infection. Small adipose tissue samples (subcutaneous

Eligibility

Inclusion criteria

Inclusion criteria: Obese: Healthy participants, male and female aged between 18-65years old with a BMI>40. Lean: Healthy participants, male and female aged between 18-65years old with a BMI<25.

Exclusion criteria

Exclusion criteria: Diabetes mellitus, hypertension, metabolic syndrome, asthma, immune disease such as Crohn colitis, rheumatic disease, cancer, use of soft/hard drugs or smoking. Previous COVID-19 infection.

Design outcomes

Primary

Measure	Time frame
Visceral and subcutaneous adipose tissue susceptibility and permissiveness to SARS-CoV-2 infection.	—

Secondary

Measure	Time frame
The response of adipose tissue-derived factors on epithelial/endothelial cell behaviour?	—

Contacts

Public ContactJill Moser

UMCG

j.moser@umcg.nl050-3610229

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)