MDMA induced memory impairment
Conditions
Interventions
Single doses of MDMA 75mg and placebo.
Sponsors
Dr J.G.Ramaekers
Dept of Neuropsychology & Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University.
Email: j.ramaekers@psychology.unimaas.nl
Eligibility
Inclusion criteria
Inclusion criteria: 1. Experience with the use of MDMA (at least 5 times in the past 12 months); 2. Free from psychotropic medication; 3. Good physical health as determined by examination and laboratory analysis; 4. Absence of any major medical (except OAC), endocrine and neurological condition; 5. Normal weight, body mass index (weight/length2) between 18 and 28 kg/m2; 6. Found suitable for fMRI as confirmed by the fMRI checklist; 7. Written Informed Consent.
Exclusion criteria
Exclusion criteria: 1. History of drug abuse (other than the use of MDMA) or addiction; 2. Pregnancy or lactation; 3. Cardiovascular abnormalities as assessed by standard 12-lead ECG; 4. Excessive drinking (> 20 alcoholic consumptions a week); 5. Hypertension (diastolic> 100; systolic> 170); 6. Current or history of psychiatric disorder; 7. Presence of metal substances/parts in the body (fMRI exclusion criterium).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Prospective and verbal memory; 2. Performance (behavior) and BOLD; 3. Response (during prospective memory task). | — |
Secondary
| Measure | Time frame |
|---|---|
| RT and no of correct responses. | — |
Contacts
Public ContactJ.G. Ramaekers
Maastricht University Dept of Neuropsychology & Psychopharmacology, Faculty of Psychology and Neuroscience, P.O. Box 616
Outcome results
None listed