cardio vascular disease, CVD, atherosclerosis
Conditions
Interventions
g, or 360 μ
g vitamin K2 respectively. And there is one placebo group which receives placebo capsules daily.
The intervention period is 12 weeks. There are two intervention groups which will receive a daily dose of 180 μ
Sponsors
?
Eligibility
Inclusion criteria
Inclusion criteria: 1. Men and women age 40-65 years; 2. Postmenopausal assed by self-report; 3. BMI 18.5-30.
Exclusion criteria
Exclusion criteria: 1. Using vitamin K antagonists; 2. Using chronic medication for cardiovascular diseases for women; 3. Using menopausal hormone therapy; 4. Smokers; 5. Using vitamin supplements that contain vitamin K, vitamin D or calcium; 6. Consuming 5 or more than 5 portions of cheese per day; 7. Consuming 200 gram or more of soft curd cheese per day; 8. Consuming 200 gram or more green vegetables per day; 9. Consuming once or more than once a week goose liver; 10. Consuming natto; 11. Vegans; 12. Known soy allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MGP levels in blood. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Blood lipid profile; 2. Inflammation markers; 3. Insulin sensitivity; 4. Adipokines; 5. Osteocalcin carboxlation. | — |
Contacts
Public ContactG.W. Dalmeijer
UMC Utrecht, Heidelberglaan 100
Outcome results
None listed