The effect of a preoperative lifestyle intervention in patients with acquired risk factors on perioperative glucose control and hemodynamics.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON24344

Enrollment

Registered

2011-09-05

Start date

2011-09-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Study subjects are identified with aquired risk factors (obesity, hypertension, dyslipidemia and physical inactivity) during health risk assessment at the Preoperative Assessment Outpatient Clinic (PAOC) and screened for impaired glucose tolerance (IGT).

Interventions

Patients in the intervention group are stimulated to increase their daily physical activity by increasing daily steps taken for a minimum of 6 consecutive weeks. Our aim is to meet the WHO guideline a

Eligibility

Inclusion criteria

Inclusion criteria: At least two out of following risk factors: 1. Obesity (BMI >30 kg/m2); 2. Hypertension (>140 mmHg systolic and/or >90 mmHg diastolic); 3. Physical inactivity (< 30 min/day of moderate activity, like walking or cycling). And: 4. Newly identified impaired glucose tolerance (IGT); 5. Age between 40 and 65 years; 6. Undergoing elective surgery not sooner than 8 weeks after the PAOC visit; 7. Abdominal/urological surgery; 8. ASA class I-III; 9. Able to walk independent of assistance.

Exclusion criteria

Exclusion criteria: 1. Prior diagnosis of diabetes mellitus; 2. Anti-hypertensive therapy; 3. Cardiovascular co-morbidity; 4. Not fit enough to participate in this study.

Design outcomes

Primary

Measure	Time frame
Changes in muscular GLUT-4 expression, intracellular Akt phosphorylation and glucose tolerance after a defined increase in physical activity in the 6 weeks before surgery.	—

Secondary

Measure	Time frame
1. Changes in physical activity during lifestyle intervention (WHO guideline, daily steps taken); 2. Influence of increased physical activity on perioperative glucose control (measured as longitudinal plasma glucose levels during surgery); 3. Influence of increased physical activity on perioperative hemodynamics (changes in heart rate and blood pressure during surgery); 4. Other changes in muscle cell that can possibly quantify increased physical activity (glycogen accumulation and fatty acid metabolism).	—

Measure

Time frame

1. Changes in physical activity during lifestyle intervention (WHO guideline, daily steps taken); 2. Influence of increased physical activity on perioperative glucose control (measured as longitudinal plasma glucose levels during surgery); 3. Influence of increased physical activity on perioperative hemodynamics (changes in heart rate and blood pressure during surgery); 4. Other changes in muscle cell that can possibly quantify increased physical activity (glycogen accumulation and fatty acid metabolism).

—

Contacts

Public ContactChrista Boer

VU University Medical Center, Department of Anesthesiology

c.boer@vumc.nl+31 (0)20 4443830

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)