cystic fibrosis
Conditions
Interventions
VIPS-MRI ( max 2x) and for healthy controls flow volume curve
Sponsors
Erasmus MC
Eligibility
Inclusion criteria
Inclusion criteria: CF patients • Diagnosed with CF with sweat and genetic testing • Age years 12-18 years • Scheduled for biennial CT scan • Willing and capable to perform spirometer controlled chest MRI • Informed consent Healthy Volunteers • Siblings or friends of the CF participants • Age 12-18 years (age and gender matched to CF patients) • Willing and capable to perform spirometer controlled chest MRI • Informed consent
Exclusion criteria
Exclusion criteria: All • MRI contraindication (i.e. cardiac pacemaker, metallic implant, hearing aids, etc.) • Claustrophobic • Pregnancy • Not willing or unable to perform MRI CF Patients • Recent (< 1 month) RTE with use of i.v. antibiotics • Chronic oxygen therapy • Any other severe comorbidities that could limit imaging Healthy volunteers • Recent (< 1 month) history of lung disease (i.e. pneumonia) • Known history of chronic lung disease (i.e. asthma) • Known history of congenital lung disease (i.e. bronchopulmonary dysplasia, tracheomalacia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To validate 2D and 3D FD as technique to assess lung ventilation compared to CT and PFT outcomes related to lung ventilation. | — |
Secondary
| Measure | Time frame |
|---|---|
| • To develop and standardize the VIPS MRI platform • To develop semi-quantitative and quantitative image analysis methods for the most clinical relevant VIPS outcome measures including outcome measures derived from fused images | — |
Contacts
Public ContactH Tiddens
Erasmus MC Sophia
Outcome results
None listed