De waarde van echo en MRI bij de evaluatie van gewrichtsschade bij hemofilie

The value of ultrasound compared to magnetic resonance imaging in haemophilic arthropathy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON24318

Enrollment

Registered

2014-08-21

Start date

2014-08-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

haemophilia, arthropathy, joint damage

Interventions

Diagnostic procedures: * Ultrasound assessment of knees and ankles * MRI assessment of knees and ankles

Eligibility

Inclusion criteria

Inclusion criteria: * Aged 18-32 year * Clinical and radiological absent or minimal arthropathy * Severe (<1% FVIII/IX activity) or moderate haemophilia (1-5% FVIII/IX activity) (* MRI assessment of both knees and ankles by the standardized MRI protocol in 2009/2010)

Exclusion criteria

Exclusion criteria: * History of inhibitors * Contra indication for MRI * Exclusion of joints in case of a severe joint injury, joint surgery, or development of a target joint since initial MRI assessment in 2009/2010

Design outcomes

Primary

Measure	Time frame
Diagnostic accuracy of ultrasound assessment of the synovium in haemophilic arthropathy compared to MRI	—

Secondary

Measure	Time frame
* Association of soft tissue changes on initial MRI with osteochondral changes on re-examination after 5 years * Reversibility of intra-articular haemosiderin	—

Contacts

Public ContactW. Foppen

University Medical Center Utrecht

w.foppen@umcutrecht.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)