A study on the Tissue Responsiveness to short term exogenous GH in children with idiopathic short stature in relation to their reponse to long-term treatment.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON24302

Enrollment

Registered

2005-09-12

Start date

1994-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Children with idiopathic short stature (ISS)

Interventions

After randomisation, the control group did not receive treatment, and were followed yearly for growth and puberty assessment. The treatment group underwent two 3 months periods of GH administration (

Eligibility

Inclusion criteria

Inclusion criteria: 40 children. Height SDS20 mU/l, normal sitting height.height ratio, normal screening blood tests and urinanalysis.

Exclusion criteria

Exclusion criteria: Any systemic disease during childhood that limits the growth potential or may interfere with the evaluation of the effectiveness of therapy.

Design outcomes

Primary

Measure	Time frame
Height at stop of therapy (at onset of puberty) and final height.	—

Secondary

Measure	Time frame
1. Timing of onset of puberty; - duration of puberty; 2. Relation between long-term growth response (dependent variable) and short-term growth response on various dosages and in vitro responsiveness of cultured skin fibroblasts to GH and IGF-I; 3. Effect of GH therapy on quality of life.	—

Contacts

Public ContactJ.M. Wit

Leiden University Medical Center (LUMC), Department of Pediatrics, P.O. Box 9600

j.m.wit@lumc.nl+31 (0)71 5262824

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)