Hypertension Hypertensie
Conditions
Interventions
Hypertensive subjects will be asked to discontinue the intake of antihypertensive medication three weeks before the start of the study. All subjects will be asked to start a low salt diet (100mmol/day
Sponsors
Prof. CDA Stehouwer
Head Department of Internal Medicine
University Hospital Maastricht
P.O. Box 5800
6202 AZ Maastricht
csteh@sint.azm.nl
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria hypertensive subjects: 1. 18-60 years 2. Caucasian 3. untreated hypertension >140/90mmHg. Inclusion criteria normotensive subjects: 1. 18-60 years 2. Caucasian 3. Blood pressure <140/90 mmHg.
Exclusion criteria
Exclusion criteria: 1. Obesity (BMI>27kg/m2) 2. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure) 3. Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA 4. Smoking 5. Alcohol use >4U/day 6. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs) 7. Pregnancy 8. Wearing contact lenses
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| functional recruitment of capillaries in the skin. | — |
Secondary
| Measure | Time frame |
|---|---|
| - perfused capillary density in the nailfold. - Endothelium- (in)dependent vasodilatation of finger skin microcirculation - Density of arterioloes, capillaries and venules in the bulbar conjunctiva. - Diameter of arterioles and venules in the bulbar conjunctiva | — |
Contacts
Public ContactA.J.H.M. Houben
Department of Internal Medicine University Hospital Maastricht P.O. Box 5800
Outcome results
None listed