Primary Sjögren's syndrome (pSS) Fatigue fMRI Cytokines Primaire syndroom van Sjögren Vermoeidheid fMRI Cytokines
Conditions
Interventions
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: Both patients and control subjects: - Age: 18-65 years - Adequate hand function that allows subjects to utilize the force transducer Patients: - Diagnosed with pSS according to AECG and/or ACR-EULAR classification criteria
Exclusion criteria
Exclusion criteria: Both patients and control subjects: - Drug or alcohol addicition - Neurologic condition unrelated to pSS - Psychiatric disorder - Other condition influencing fatigue - Medication influencing fatigue or the immune system - fMRI related exclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Maximal force of the first dorsal interosseous (FDI) muscle - Force decline during the fatiguing task - Muscle activation during the fatiguing task - Questionnaire scores - Changes in cortical activation during the fatiguing task (functional MRI data). | — |
Secondary
| Measure | Time frame |
|---|---|
| - Ectromyographic activity of the FDI muscle during the motor tasks | — |
Contacts
Public ContactC.A.T. Zijdewind
Dept Neuroscience, Section Medical Physiology, HPC-FB43 University Medical Center Groningen
Outcome results
None listed