Chronic kidney disease, end-stage renal disease, hemodialysis, hyperphosphatemia
Conditions
Interventions
The intervention is a dose reduction of phosphate binding therapy in combination with personalized pharmacist-led counselling.
Sponsors
Franciscus Gasthuis and Vlietland
Eligibility
Inclusion criteria
Inclusion criteria: - Both the mean serum phosphate level over the last 3 months and the last serum phosphate level are higher than 1.5 mmol/L. - Prescription for 6 or more phosphate binder units daily - Age of 18 years or older - Medication dispensed by Poli-apotheek Franciscus Gasthuis - Intermittent hemodialysis for at least 3 months preceding the inclusion date. - Hemodialysis during entire follow-up - Sufficient language proficiency to comprehend instructions concerning study procedures, such as informed consent.
Exclusion criteria
Exclusion criteria: - Patients residing in a nursing home - Cognitive impairment, resulting in failure to comprehend instructions concerning study procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome variable is the difference between the mean serum phosphate level over the 3 months before the intervention, and the mean serum phosphate level over the first 3 months after the intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| • the percentage of patients with a mean serum phosphate level of 1.5 mmol/L or lower, measured the 3 months before and 3, 6 and 12 months after the intervention. • the trend in serum phosphate level during follow-up • the difference between the mean serum phosphate level over the 3 months before the intervention, and the serum phosphate level at 6 and 12 months after the intervention • the implementation fidelity of the intervention, including barriers and facilitators for implementation • pharmaceutical literacy • medication adherence (MARS-5) before and after the intervention | — |
Contacts
Public ContactFrancisca Johanna van den Oever
Franciscus Gasthuis and Vlietland
Outcome results
None listed