Renal artery stenosis, renovascular disease, hypertension, chronic kidney disease
Conditions
Interventions
The study will compromise a series of intra-renal pressure and flow measurements that are consecutively performed at rest, during exercise induced minimal flow, and during hyperemia. The measurements
Sponsors
Academic Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: Age > 18 Written informed consent Clinically and hemodynamically stable Clinical indication for a coronary, renal, or peripheral vascular angiography with or without percutaneous intervention.
Exclusion criteria
Exclusion criteria: Recent ST-segment elevation myocardial infarction ( II) Increased risk for contrast nephropathy defined as presence of renal impairment (eGFR <30ml/min) according to the Guideline Safe Use of Contrast Media of the Radiology Society of the Netherlands (November 2017) Women of child bearing age not on active birth control Inability to sign an informed consent, due to any mental condition that renders the subject unable to understand the nature, scope, and possible consequences of the trial or due to mental retardation or language barrier
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dynamic range of renal blood flow, represented by the relative baseline flow (RBF), the ratio between the difference of baseline and minimal flow velocity and baseline flow velocity. | — |
Secondary
| Measure | Time frame |
|---|---|
| Renal flow reserve, relative minimal flow, renal fractional flow reserve, baseline and hyperemic renal stenosis resistance, baseline and hyperemic microvascular resistance, phase difference in sympathetic band for autoregulation. In patients where offline renal perfusion analysis is possible: renal perfusion as area under the curve of contrast density over time and the renal flow reserve computed by perfusion angiography. Correlation of main study parameters with relevant clinical, biochemical and imaging parameters. | — |
Contacts
Public ContactDidier Collard
Amsterdam UMC - location AMC
Outcome results
None listed