Cystic Fibrosis Taaislijmziekte Inhalationprofile Inhalatieprofiel Deposition Depositie
Conditions
Interventions
During the second home visit patients will be instructed to inhale as fast as possible, either the first or the second pair of four inhalations of tobramycin capsules. They will also be asked to inhal
Sponsors
Erasmus MC
Eligibility
Inclusion criteria
Inclusion criteria: Proven CF Maintenance treatment with TIP Age of 6 and older Informed consent by parents or patients
Exclusion criteria
Exclusion criteria: Respiratory tract exacerbation at time of TIP month defined as treatment with intravenous antibiotics Any other acute condition such as otitis media which according to the treating physician will increase the risk of cough during the inhalation maneuvers. Inability to follow instructions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the percentage of patients who inhale with a slow/ intermediate/ fast inhalation maneuver while inhaling TIP. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are: Difference in percentage of patients who react with cough immediately during or following TIP inhalation for the slow/intermediate/fast inhalation maneuver, prevalence of errors made in TIP inhalation in the home situation according to scoring items list, percentage of patients able to execute a slow and deep inhalation using TIP, and tidal volume pattern while patients are inhaling from a conventional nebulizer | — |
Contacts
Public ContactH.A.W.M. Tiddens
Erasmus Medical Center, Sophia Children’s Hospital Rotterdam, Department of Pediatric Pulmonology, Dr. Molewaterplein 60
Outcome results
None listed