Alzheimer's Disease
Conditions
Interventions
Duration of intervention: 24 weeks.
Intervention group: all participants in the intervention group will receive daily 125 ml of Souvenaid®. Souvenaid(r) is a 125ml (125kcal) once-a-day multi-nutrient
Sponsors
Danone Research – Centre for Specialised Nutrition
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of probable AD according to the NINCDS-ADRDA criteria; 2. MMSE score 14-24; 3. Use of approved anti-AD medication on a stable dose for at least four months prior to baseline and anticipated stable use throughout the entire study period; 4. Age 50 years or older; 5. Availability of responsible caregiver; 6. Written informed consent of patient and caregiver.
Exclusion criteria
Exclusion criteria: 1. Diagnosis of significant neurological/ psychiatric disease other than AD; 2. Geriatric Depression Scale > 4 on 15-item scale; 3. Use within two months prior to baseline of: A. Omega-3 fatty acid containing supplements; B. Oily fish (when consumed more than twice a week). 4. Alcohol or drug abuse in opinion of the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive Performance (ADAS-cog) during 24 weeks of intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. ADCS-ADL; 2. Cognitive test battery; 3. CDR-SOB; 4. Nutritional blood parameters; 5. Tolerance and safety. All during 24 weeks of intervention. | — |
Contacts
Public ContactRico L. Wieggers
Danone Research – Centre for Specialised Nutrition PO Box 7005
Outcome results
None listed