Lung failure Nebulisation Mechanical ventilation Bronchodilator (salbutamol) Mucolytic (acetylcysteine)
Conditions
Interventions
Routine nebulisation of mucolytics and bronchodilators administered every 6 hours is compared to nebulisation of mucolytics and bronchodilators on strict clinical indication (i.e., only if a patient s
Sponsors
Academic Medical Center Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: Age 18 year or older Expected duration of intubation and ventilation > 24 hour Written informed consent
Exclusion criteria
Exclusion criteria: Ventilation before present ICU admission (though short-term ventilation in the emergency room or in the operation room for general anesthesia during surgery is allowed) Pregnancy Lung disease for which inhalation therapy and/or oral steroids are used Diagnoses of: Guillain-Barré syndrome, complete spinal cord lesion or amyotrophic lateral sclerosis, multiple sclerosis and myasthenia gravis Allergy for acetylcysteine or salbutamol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of ventilator-free days (VFDs), defined as the number of days from day 1 to day 28 after ICU admission and start of mechanical ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| -ICU and hospital length of stay -ICU and hospital mortality -secondary ARDS -ventilator-associated pneumonia -atelectasis -side effects of nebulisation of mucolytics and bronchodilators -related health care costs will be estimated with a cost benefit – and budget impact analysis | — |
Contacts
Public ContactSophia Hoeven, van der
Department of Intensive Care Academic Medical Center, University of Amsterdam Meibergdreef 9, G3-228
Outcome results
None listed