autoimmune hepatitis, drug-induced liver injury, non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
Conditions
Interventions
One extra needle passage during a liver biopsy that is part of usual care.
Sponsors
Investigator initiated study, funded by the Vrije Universiteit, University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: Indication for a biopsy for the diagnosis or monitoring of; AIH, DILI, NAFL or NASH Eligible for liver biopsy ¡Ý 18 years old Provide informed consent
Exclusion criteria
Exclusion criteria: Contraindication for liver biopsy, determined by the clinician. Current infectious disease. Clinically relevant cardiovascular, pulmonary, or renal disease. Medications with possible immune-modulating effects (e.g., steroids). (a history of) alcohol or drug abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immunophenotype of intrahepatic leucocytes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Histology outcome | — |
Outcome results
None listed