Type 2 Diabetes Mellitus, Insulin Resistance, Skeletal muscle, Lipid accumulation
Conditions
Interventions
Ten healthy, lean, untrained male subjects (age 18-35
BMI ≤
25 kg/m2) will undergo, in a randomized crossover design, a 6h-hyperinsulinemic euglycemic clamp (to assess insulin sensitivity) with simultaneous lipid infusion. In the first condition, the lipid inf
Sponsors
NUTRIM - Maastricht University
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male sex; 2. Age 18-35 years; 3. BMI <25 kg/m2; 4. Sedentary; 5. Stable dietary habits; 6. Healthy.
Exclusion criteria
Exclusion criteria: 1. Female sex; 2. First or second-degree family member with diagnosed type 2 diabetes or any other endocrine disorder; 3. Participation in a regular exercise training program during the last year before the start of the study; 4. The use of any plasma glucose lowering medication; 5. Participation in another biomedical study within 1 month before the first screening visit.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Accumulation of lipid species in skeletal muscle; 2. Insulin sensitivity. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Substrate oxidation; 2. Energy expenditure; 3. Gene expression. | — |
Contacts
Public ContactPatrick Schrauwen
Postbus 616 Department of Human Biology Maastricht University Medical Center
Outcome results
None listed