healthy volunteers
Conditions
Interventions
Placebo and 5, 10, 20 µg of LSD
Sponsors
Maastricht University
Department of Psychology and Neurosciences
Eligibility
Inclusion criteria
Inclusion criteria: • Previous experience with a psychedelic drug, but not within the past 3 months. • Proficient knowledge of the English language • Written Informed Consent • Understanding the procedures and the risks associated with the study. • Age between 18 and 40 years • Absence of any major medical condition as determined by medical examination and laboratory analysis • Absence of any major psychological condition as determined by medical examination • Free from psychotropic medication • Participants must be willing to refrain from taking illicit psychoactive substances during the study. • Participants must be willing to drink only alcohol-free liquids and no coffee, black or green tea, or energy drink after midnight of the evening before the study session, as well as during the study day. • Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after substance administration. • Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2
Exclusion criteria
Exclusion criteria: • History of drug addiction (determined by the medical questionnaire, drug questionnaire and medical examination) • Previous experience of serious side effects to psychedelic drugs (anxiety or panic attacks) • Pregnancy or lactation • Hypertension (diastolic > 90 mmHg; systolic > 140 mmHg) • Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination) • Psychotic disorder in first-degree relatives • Any chronic or acute medical condition • History of cardiac dysfunctions (arrhythmia, ischemic heart disease,…) • For women: no use of a reliable contraceptive • Tobacco smoking (>20 per day) • Excessive drinking (>20 alcoholic consumptions per week)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective is to characterize the dose-response relationship in LSD-induced subjective effects. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objective is to characterize the dose-response relationship in LSD-induced changes in cognitive performance. | — |
Contacts
Public ContactMaastricht University FPN-LSD Microdosing
Outcome results
None listed