The effect of high dose statins (Simvastatin 80 mg) on vascular inflammation in the abdominal aneurysm.

Het effect van hoog gedoseerde statine-therapie (simvastatine, 80 mg) op de ontstekingsactiviteit in het abdominale aneurysma.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON24165

Enrollment

Registered

2010-07-08

Start date

2010-07-15

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal Aortic Aneurysm

Interventions

Simvastatin 80 mg OID.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age >18; 2. Open elective AAA repair; 3. Current statin use.

Exclusion criteria

Exclusion criteria: 1. Statin intolerance; 2. Renal impairment (clearance <30 ml/min); 3. Liver impairment; 4. Excess alcohol consumption; 5. Any chronic inflammatory conditions; 6. Use of one or more of the following pharmaceutical agents: Itraconazol, Ketoconazol, Erytromycine, Claritromycine, Ciclosporine, Fibrates, immuo suppressives or HIV-protease inhibitors; 7. Inflammatory aneurysm.

Design outcomes

Primary

Measure	Time frame
Aortic wall IL6, IL8 and MCP-1 levels.	—

Secondary

Measure	Time frame
1. Aortic wall cell counts; 2. Aortic wall protease expression; 3. Aortic wall transcription factor activation.	—

Contacts

Public ContactJan H. Lindeman

Leiden University Medical Center Dpt. of Vascular Surgery. PO-box 9600

Lindeman@lumc.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)