heart failure, exercise training, vascular shear rate hartfalen, inspanning, training, bloedflow patronen
Conditions
Interventions
1. Moderate-intensity continuous exericse
2. High-intensity interval exercise.
Maximal load and physical fitness level will be measured by the maximal wattage and peak oxygen uptake during an incremental cycling test (power will be increased
Sponsors
Radboud University Nijmegen Medical Centre
Eligibility
Inclusion criteria
Inclusion criteria: Patient group: 1. Patients diagnosed with heart failure NYHA class II/III; 2. ≥ 18 years of age; 3. Mentally able/allowed to give informed consent. Control group: 1. Subjects free of cardiovascular disease and/or cardiovascular medication; 2. ≥ 18 years of age; 3. Mentally able/allowed to give informed consent.
Exclusion criteria
Exclusion criteria: 1. Contra-indications for exercise testing; 2. Pathology/disease that restricts patients from participation to exercise; 3. Serious co-morbidity. For the use of the telemetric pill specific contra-indications are formulated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Oscillatory index; 2. Brachial artery blood flow patterns (antegrade and retrograde shear rate). Diameter of the right brachial artery and velocity of the blood flow will be examined using the non-invasive echo-Doppler. A 2-minute baseline recording will be acquired before starting the training session. A recording of the first ten minutes of the exercise session will be acquired continuously, while 1-minute ultrasound recordings are made every 5 minutes throughout the rest of the exercise session. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Thermoregulatory changes (skin and core body temperature); 2. Autonomic function (heart rate variability). | — |
Contacts
Public ContactNathalie M.M. Benda
Phililps van Leijdenlaan 15
Outcome results
None listed