Sarcopenia
Conditions
Interventions
Duration of intervention: 4 weeks
Intervention and Control group:
Subjects will be randomised into one of four groups:
Group I: receiving product A, B, C and D in visit 1, 2, 3 and 4 respectively
Sponsors
Nutricia Research – Centre for Specialised Nutrition
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 65 years or older 2. BMI from 20 through 30 kg/m2
Exclusion criteria
Exclusion criteria: 1. Any gastrointestinal (GI) disease that interferes with GI function 2. Known renal or hepatic failure 3. Known or suspected Diabetes Mellitus (fasting glucose level ≥ 7.0 mmol/L) 4. (History of) any cancer with the exception of basal cell carcinoma 5. Fever in the last 7 days prior to Visit 1 6. Haemoglobin in men 3 kg in last 3 months) 9. Adherence to a weight loss programme 10. Use of protein containing or amino acid containing nutritional supplements within one week of Visit 1 11. Current or recent (within past 3 months) smoking 13. Known allergy to the ingredients of the study products 14. Known galactosaemia 15. Blood donation within 2 months of study entry and during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome parameter in this study is the Leucine Cmax [μmol/L] (product A compared to product B). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome parameters in this study are comparison of product A and B on: • Leucine iCmax [μmol/L], iAUC [μmol/L*min] and t½ iAUC [min] • Essential aminoacids Cmax [μmol/L], iCmax [μmol/L], iAUC [μmol/L*min] and t½ iAUC [min] • Total sum aminoacids Cmax [μmol/L], iCmax [μmol/L], iAUC [μmol/L*min] and t½ iAUC [min] • Adverse events and (Gastro-Intestinal) tolerance questionnaire | — |
Contacts
Public ContactCarolien Buurman
Nutricia Research PO Box 80141 3508 TC Utrecht
Outcome results
None listed