Investigating the sensitivity of the central nervous system in patients with chronic low back pain radiating to the leg

Central sensitisation in patients with chronic low back pain radiating to the leg

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON24108

Enrollment

100

Registered

2018-01-10

Start date

2018-02-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic low back pain, central sensitisation, segmental nerve root block, pulsed radiofrequency

Interventions

This study will include 50 patients and 50 age and gender matched controls. Patients will receive care as usual. Segmental nerve intervention will be performed according to the standard procedures o

Eligibility

Inclusion criteria

Inclusion criteria: - Presence of CLBP radiating to the leg; - Leg pain >= back pain; - Physician must consider therapeutic Sensory Nerve Root Blocking (SNRB) or pulsed RadioFrequency (pRF) as an appropriate treatment intervention; - Age: 18-65 years old; - Agreement and signature of the informed consent

Exclusion criteria

Exclusion criteria: - Exclusion criteria for segmental nerve blocks (according to local protocol) - No or not sufficient understanding of Dutch language; - Incapacity to follow instructions; - Mental incompetence to provide informed consent; - CLBP with radiation to both legs; - Pain in one (or more) sites where BSE and QST will be applied (except for the most painful point in the painful dermatome).

Design outcomes

Primary

Measure	Time frame
1. Quantitative Sensory Testing (QST; T1,T1a,T1b,T2,T3) 2. Bedside Examination (BSE; T1,T1a,T1b,T2,T3) 3. Central Sensitization Inventory (CSI; T1,T1a,T1b,T2,T3)	—

Secondary

Measure	Time frame
1.36-Item Short Form Health Survey (SF-36; T1,T3) 2.Pain Disability Index (PDI; T1,T3) 3.Work Ability Index (WAI; T1,T3) 4.STarT Back Screening Tool (SBST; T1,T3) 5.Numeric Rating Scale for Pain(VAS; T1,T1a,T1b,T2,T3) 6.Drawing in standard leg images (DPA; T1,T3) 7.Pain Catastrophising Scale (PCS; T1, T3) 8.Pain Vigilance and Awareness Questionnaire (PVAQ; T1,T3)	—

Contacts

Public ContactR. Spanjersberg

Hanzeplein 1

r.spanjersberg@umcg.nl+31 (0)50 3611158

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Mar 3, 2026