anovulatory WHO class II women, ovulatory with clomiphene citrate.
Conditions
Interventions
At least one PCT is performed during the basic fertility work-up. The test should be planned based on the basal body temperature (BBT) curve, ultrasound findings or cycle history. In couples where the
Sponsors
Medisch Spectrum Twente Enschede
Academisch Medisch Centrum Amsterdam
Vrije Universiteit Medisch Centrum Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1. WHO class II anovulatory women who ovulate following use of incremental CC doses from 50 to 150 mg starting on dag 3-5 following 5 days of the cycle; 2. All patients have normal serum prolactin (0,05 ¨C 0,80 IU/l) and thyroid-stimulating hormone (0,4 - 4,0 mU/l); 3. Age > 18 years; 4. A partner with total motile sperm count above 1 million, according to the modified criteria of the World Health Organization (1999).
Exclusion criteria
Exclusion criteria: 1. Women who remain anovulatory on CC 150 mg or who become anovulatory after initial ovulation; 2. Known bilateral tubal obstruction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure is the occurrence of an ongoing, vital intra-uterine singleton pregnancy. An ongoing, vital pregnancy is defined as fetal heart beat seen by transvaginal ultrasonography at 12 weeks gestation. If no pregnancy occurs, follow-up ends after the sixth cycle. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Positive pregnancy test; 2. Occurrence of ovulation; 3. Total number of postcoital tests performed; 4. Median time to pregnancy; 5. Clinical pregnancy, defined as any registered heart beat at sonography; 6. Miscarriage, defined as loss of an intra uterine pregnancy (confirmed by ultrasound or histologic examination) before the 20th week of pregnancy; 7. Multiple pregnancy, defined as a registered heart beat of at least two fetuses at 12 weeks of gestation. | — |
Contacts
Public ContactMarleen J Nahuis
Medisch Spectrum Twente Locatie Enschede Ariënsplein
Outcome results
None listed