Growth Hormone Growth hormone deficiency Diagnostic problems of growth hormone tests
Conditions
Interventions
None listed
Sponsors
Maastricht University Medical Centre (MUMC)
PO box 5800
6202 AZ Maastricht
The Netherlands
Telephone +31 43 387 5239
Eligibility
Inclusion criteria
Inclusion criteria: 1. All children scheduled for growth hormone treatment, fulfilling the next criteria: A. Children born small for gestational age without catch up growth; B. Children born with a birth length and/or weight < -2 SDS for gestational age (Niklasson); C. Short stature defined as height SDS below -2.5 according to the Dutch National Growth References of 1997 and height of ≥ 1.3 SDS below target height SDS. 2. Children with growth hormone deficiency: A. GHD is confirmed in all patients who during an arginine and clonidine provocation test show a peak GH level of < 20 mU/l. 3. Informed consent; 4. Age ≥ four years.
Exclusion criteria
Exclusion criteria: 1. Children with a chronological or bone age greater than 8 years for girls and 10 years for boys, because of the influence of puberty; 2. Children younger that 4 years of age; 3. Children with syndromes or diseases that influence growth otherwise than GDH or SGA; 4. Expected non-compliance based on earlier knowledge over the patient by the opinion of the endocrinologist.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The relation between short time effects of rhGH treatment on total body water (TBW) and total energy expenditure (TEE) in growth hormone deficient and small for gestational age children and the long-term change in height SDS after one year. | — |
Secondary
| Measure | Time frame |
|---|---|
| What effect has GH on a number of metabolic risk parameters that are typical parameters for the metabolic syndrome in adults? | — |
Contacts
Public ContactD.A. Schott
Department of paediatrics Maastricht University Medical Centre (MUMC) PO box 5800
Outcome results
None listed