Type 2 diabetes mellitus, Coronary heart disease, Subthreshold depression, Depression prevention, Quality of life, Economic evaluation, Stepped-Care, Primary care
Conditions
Interventions
The intervention is modeled after the flexible stepped-care intervention by Van 't Veer-Tazelaar et. al. (2009) The nurse-led stepped-care program consists of four evidence-based treatment steps, last
Sponsors
VU University, Amsterdam, The Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diabetes type 2 and/or coronary heart disease; 2. Age 18 or older; 3. Treated for diabetes and/or coronary heart disease in primary care; 4. Subthreshold depression (PHQ-9 score 6 or higher and MINI interview negative for major depressive disorder).
Exclusion criteria
Exclusion criteria: 1. Major depressive disorder; bipolar disorder according to the MINI; 2. Cognitive impairment or dementia; 3. Borderline, schizoid or schizotypal personality disorder; 4. Psychotic illness; 5. Terminal illness; 6. Currently taking antidepressant medication; 7. A history of suicide attempt(s); 8. Insufficient Dutch language skills; 9. Visual impairments or illiteracy; 10. Complete deafness; 11. Loss of significant other < previous 6 months; 12. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Primary clinical outcome is the cumulative incidence of DSM-IV major depressive disorder after 12 months using the Mini International Neuropsychiatric Interview (MINI); 2. In the economic evaluation, health care utilization and absenteeism and presenteeism will be measured using the most recent update of the TiC-P questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Quality of life (EuroQol-5D); 2. Depression severity (PHQ-9); 3. HBa1c; 4. Bloodpressure; 5. LDL cholesterol; 6. Anxiety symptoms (HADS). | — |
Contacts
Public ContactSusan Dijk, van
VU University, health Sciences Department De Boelelaan 1085
Outcome results
None listed