The effect of dopamine depletion on endogenous glucose production in healthy subjects.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON24057

Enrollment

Registered

2009-09-09

Start date

2009-01-10

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus type II (DMII) insulin resistance/ insuline resistentie

Interventions

Each subject will be studied twice. Once after dopamine depletion (with AMPT) and once after placebo. We will perform a 2-step hyperinsulinemic euglycemic clamp, using stable isotopes.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Healthy men; 2. Age: 18-35 years; 3. BMI: 20-25 kg/m2.

Exclusion criteria

Exclusion criteria: 1. DM type I and II or any other chronic disease; 2. Renal insufficiency or elevated liver enzymes; 3. Family history of DMII; 4. Primary dyslipidemia; 5. Use of any drugs and history of drug abuse; 6. Alcohol consumption >3/day; 7. Performance of vigorous exercise; 8. History of psychiatric disorders.

Design outcomes

Primary

Measure	Time frame
Endogenous glucose production.	—

Secondary

Measure	Time frame
1. Peripheral insulin sensitivity; 2. Lympathetic activity; 3. Glucoregulatory hormones.	—

Contacts

Public ContactN.M. Lammers

Academic Medical Centre (AMC) Department of Endocrinology & Metabolism F5-162

N.M.Lammers@amc.uva.nl+31 (0)20 5662663

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)