Delirium, circadian rhythm, acute confusional state, ICU delirium, delier, acute verwardheid, melatonin, melatonine, circadiane ritme, elderly, ouderen
Conditions
Interventions
This is an observational study. Waste material of daily blood samples taken for clinical reasons will be analysed. If there is no blood sample taken for clinical reasons around 3am, 6am, 3pm and 11pm,
Sponsors
Academic Medical Centre Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: - Age 60 years or above - Patients or their legal representative must be able to give informed consent - Inclusion directly after ICU admission, but at least within 24 hours of admission - Expected admission to the ICU for longer than one day - Medical or surgical reason for admission to the ICU
Exclusion criteria
Exclusion criteria: - Stroke as the reason for hospital admission - Chronic use of antidepressants or antipsychotics before ICU admission - Use of melatonin before or during hospital admission - Dialysis before admission - History of diagnosed dementia - Absence of arterial or venous catheter
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the peak concentration and the secretion patterns of melatonin of older persons admitted to the ICU with and without delirium during the study days at a maximum of seven consecutive days. | — |
Secondary
| Measure | Time frame |
|---|---|
| To investigate whether, besides delirium, mechanical ventilation, renal failure, sepsis or (nor) adrenergic stimulation influence melatonin in patients admitted to the ICU | — |
Contacts
Public ContactR.M. Scholtens
Afdeling Interne geneeskunde/Geriatrie AMC Meibergdreef 9
Outcome results
None listed